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DeCS
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Descriptor English:
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Dactinomycin
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Descriptor Spanish:
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Dactinomicina
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Descriptor Portuguese:
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Dactinomicina
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Synonyms English:
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Ac-De
Cosmegen
Cosmegen Lyovac
Lemery Brand of Dactinomycin
Lyovac-Cosmegen
MSD Brand of Dactinomycin
Merck Brand of Dactinomycin
Merck Frosst Brand of Dactinomycin
Merck Sharp & Dohme Brand of Dactinomycin
Lyovac, Cosmegen
Actinomycin D
Meractinomycin
Actinomycin
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Tree Number:
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D03.633.300.200
D04.345.566.252
D12.644.641.252
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Definition English:
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A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) |
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Pharmacological Action:
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Anti-Bacterial Agents
Antibiotics, Antineoplastic
Nucleic Acid Synthesis Inhibitors
Protein Synthesis Inhibitors
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History Note English:
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66; ACTINOMYCIN was heading 1963-95
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Allowable Qualifiers English:
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Record Number:
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3628
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Unique Identifier:
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D003609
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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